Aspirina e HIV:riduce il rischio cardiovascolare e non solo?
Inviato: domenica 9 settembre 2012, 22:01
E' già stato riportato un breve accenno nel report di Sheep per Natap e postato qua http://hivforum.info/forum/viewtopic.ph ... 6&start=10
has both anti-thrombotic and anti-inflammatory effects, is inexpensive, has a well established adverse effect profile and is widely used for long-term CVD prevention. O’Brien et al. (THAB0202) reported a pilot study examining the effects of daily low dose (81 mg) daily ASA in both HIV-infected patients on ART and healthy volunteers. After one week, ASA significantly reduced the abnormal levels of platelet aggregation, soluble p-selectin (a marker of activated platelets an endothelial cells), CD4+ and CD8+ T-cell activation (CD38+/HLA-DR+) and sCD14 (a marker of monocyte activation) found in HIV-infected subjects. Leukocyte responsiveness to TLR-4 agonists, an important component of the innate immune response to microbial translocation was also improved.
Riprendo la questione riportando all'attenzione l'articolo di Tim Horn perchè se davvero questo studio dovesse essere confermato nel tempo, l'aspirina è uno di quei farmaci che io personalmente ho sempre ritenuto ottimo e indispensabile oltre ad essere studiato da quel dì, e ha un costo molto basso.
http://www.poz.com/articles/hiv_aspirin ... 2855.shtml
has both anti-thrombotic and anti-inflammatory effects, is inexpensive, has a well established adverse effect profile and is widely used for long-term CVD prevention. O’Brien et al. (THAB0202) reported a pilot study examining the effects of daily low dose (81 mg) daily ASA in both HIV-infected patients on ART and healthy volunteers. After one week, ASA significantly reduced the abnormal levels of platelet aggregation, soluble p-selectin (a marker of activated platelets an endothelial cells), CD4+ and CD8+ T-cell activation (CD38+/HLA-DR+) and sCD14 (a marker of monocyte activation) found in HIV-infected subjects. Leukocyte responsiveness to TLR-4 agonists, an important component of the innate immune response to microbial translocation was also improved.
Riprendo la questione riportando all'attenzione l'articolo di Tim Horn perchè se davvero questo studio dovesse essere confermato nel tempo, l'aspirina è uno di quei farmaci che io personalmente ho sempre ritenuto ottimo e indispensabile oltre ad essere studiato da quel dì, e ha un costo molto basso.
http://www.poz.com/articles/hiv_aspirin ... 2855.shtml